Ionizing radiation regulates expression of the c-jun protooncogene.
نویسندگان
چکیده
منابع مشابه
Ionizing radiation regulates expression of the c-jun protooncogene.
There is little known about the regulation of gene expression by ionizing radiation exposure. The present studies demonstrate transcriptional activation of a mammalian gene, the c-jun protooncogene, by x-rays. The c-jun gene encodes a component of the AP-1 protein complex and is important in early signaling events involved in various cellular functions. The increase in c-jun transcripts by ioni...
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A prototypic "immediate early" gene, c-fos, has been extensively investigated in relation to the differentiation and activation of myelomonocytic cells. The c-fos gene product is associated in transcriptional complexes with the c-jun product. These protooncogenes are part of the regulatory network of gene expression. The present study was designed to investigate expression of the c-jun protoonc...
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We isolated a clone containing rat c-jun gene from a rat liver and is highly conserved when compared with that of human cgenomic DNA-X charon 4A library by plaque hybridization with jun gene (4). Nucleotide numbers are given with the initiation P-labeled human c-jun cDNA (1) and determined the site of transcription as +1 . nucleotide sequence. The rat gene encodes a protein whose deduced amino ...
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We have recently demonstrated that certain camptothecin derivatives are effective agents in the treatment of human tumor xenografts in nude mice. While camptothecin and its derivatives are recognized as inhibitors of topoisomerase I, little is known about the effects of these agents on specific gene expression, particularly genes involved in growth control. The c-jun early response gene codes f...
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We have recently demonstrated that certain camptothecin derivatives are effective agents in the treatment of human tumor xenografts in nude mice. \Yhile camptothecin and its derivatives are recognized as inhibitors of topoisomerase I, little is known about the effects of these agents on specific gene expression, particularly genes involved in growth control. The c-jun early response gene codes ...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1990
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.87.15.5663